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Saturday, July 25, 2020 | History

2 edition of Intestinal paracellular drug absorption. found in the catalog.

Intestinal paracellular drug absorption.

Sarah Jane Bumstead

Intestinal paracellular drug absorption.

by Sarah Jane Bumstead

  • 272 Want to read
  • 20 Currently reading

Published by University of Manchester in Manchester .
Written in English


Edition Notes

Thesis (M.Sc.), - University of Manchester, Department of Pharmacy.

ContributionsUniversity of Manchester. Department of Pharmacy.
The Physical Object
Pagination153p.
Number of Pages153
ID Numbers
Open LibraryOL16573370M

Intestinal transit time can influence drug absorption, particularly for drugs that are absorbed by active transport (eg, B vitamins), that dissolve slowly (eg, griseofulvin), or that are polar (ie, with low lipid solubility; eg, many antibiotics). Background: Information on the bioavailability of the essential mineral Mg2+ is sparse. Objective/Method: Evaluation of the present knowledge on factors influencing the bioavailability and intestinal absorption of Mg2+. Results: Mg2+ is absorbed via a paracellular passive and a transcellular active pathway that involves TRPM6/7 channel caskel.com by:

@article{osti_, title = {Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells}, author = {Artursson, P. and Karlsson, J.}, abstractNote = {Monolayers of a well differentiated human intestinal epithelial cell line, Caco-2, were used as a model to study passive drug absorption across the intestinal. Dec 01,  · The absorption of drugs via the oral route is a subject of intense and continuous investigation in the pharmaceutical industry since good bioavailability implies that the drug is able to reach the systemic circulation by mouth. Oral dry absorption is affected by both drug properties and the.

Jan 02,  · The mechanism of transcellular absorption relies on either gradient-based transportation or membrane-driven active transport to bring molecules in and out of the intestinal cells. Paracellular transport uses the actin-myosin cytoskeletal system and 3 paracellular structures called desmosomes, adherins junctions, and tight junctions, to prevent. Feb 19,  · Human Intestinal Stem Cell-derived Mini-intestines: Enteroids Versus Organoids. Currently, the two primary ways to generate human mini-intestines include (a) isolation of intestinal crypts, which contain human adult stem cells, from donors or (b) use of human embryonic or inducible pluripotent stem cells (iPSCs). 3 Both methods have been described in detail and reviewed elsewhere Cited by:


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Intestinal paracellular drug absorption by Sarah Jane Bumstead Download PDF EPUB FB2

Intestinal drug absorption can be improved by altering paracellular and transcellular transport pathways using permeation enhancers (Figure ) [16–19].Permeation enhancers have different mechanisms of action, including the induction of a loss of integrity of the cell–cell tight junctions, changes in mucus viscosity, Intestinal paracellular drug absorption.

book of membrane structure and fluidity – associated with. Intestinal Absorption Enhancement Via the Paracellular Route by Fatty Acids, Chitosans and Others: A Target for Drug Delivery.

Author(s): Maria Jose Cano-Cebrian, Teodoro Zornoza, Luis. Paracellular transport also has the benefit that absorption rate is matched to load because it has no transporters that can be saturated.

In most mammals, intestinal absorption of nutrients is thought to be dominated by transcellular transport, e.g., glucose is primarily absorbed via the SGLT1 transporter and other glucose transporters. The intestinal permeability of an orally administered drug (given the value Peff) has been widely used to determine the rate and extent of the drug’s intestinal absorption (Fabs) in humans.

Feb 22,  · Uptake and efflux transporters are implicated as facilitating or limiting intestinal absorption. This book chapter will touch up on the latest findings on several chemistry approaches that has be directed to target the uptake transporters and circumvent the efflux transporters.

In paracellular diffusion, drug molecules are absorbed by Cited by: Ensuring a sufficient compound concentration in solution at the primary site of absorption is a requirement for successful oral drug absorption. Cyclodextrins improve oral absorption and bioavailability of drug molecules via the increase of drug solubility, dissolution rate, and/or intestinal permeability.

Purpose. Medium chain fatty acid salts promote absorption by increasing paracellular permeability of the intestinal epithelium. Novel oily suspension (OS) formulation disperses a powder containing sodium caprylate and macromolecules such as octreotide or fluorescent dextran (FD).Cited by: This transport can either be absorption, transport from lumen (apical membrane surface) to blood, or secretion, transport from blood (basolateral membrane surface) to lumen.

The transcellular pathway of transport is important in the intestinal absorption of drug molecules, the. Oct 15,  · Intestinal hexose absorption: transcellular or paracellular fluxes.

Chris I Cheeseman these transcellular pathways for the intestinal absorption of hexoses have been calculated to have a limited capacity and appear to provide a rather low safety margin for the complete absorption of dietary While I have retained a paracellular route Cited by: Oral Absorption, Intestinal Metabolism and Human Oral Bioavailability Uptake and efflux transporters are implicated as facilitating or limiting intestinal absorption.

This book chapter will touch up on the latest findings on several chemistry In paracellular diffusion, drug molecules are ab sorbed by diffusion and convective volume. for the absorption of various drug molecules across the intestinal membrane (Winne ; Hayton ). The thickness of this layer in humans is only 25 μ m (Strocchi et al.

Maximizing drug absorption from the intestine is a critical goal in human therapeutics. Although efflux transporters and metabolizing enzymes are recognized as important barriers to intestinal drug absorption, the interplay between these factors is not well studied and is.

Colonic absorption of poorly absorbable cefmetazole was shown to increase considerably by the addition of 1% sodium caprate, sodium laurate, and mixed micelles composed of sodium oleate and sodium taurocholate. At %, their effects were weaker but still significant.

Colonic absorption of inulin was also increased by the promoters at a concentration of %. These results suggest that there Cited by: Feb 26,  · • The rate of absorption by active transport can be determined by applying the equation used for Michalies-menten kinetics: dc = [C].(dc/dt)max dt Km + [C] Where, (dc/dt)max = maximal rate of drug absorption at high drug concentration.

[C] = concentration of drug available for absorption Km = affinity constant of drug for the barrier. MLA Proctor, William Ross, Iii. A Novel Mechanism for Intestinal Absorption of the Type Ii Diabetes Drug Metformin: Role of Cation-selective Apical Transporters In Paracellular caskel.com by: 2.

Describe how drug absorption may be affected by a disease that causes changes in intestinal blood flow and/or motility. List the major factors that affect drug absorption from oral and nonoral routes of drug administration.

Describe various methods that may be used to study oral drug absorption from the gastrointestinal transit. + +. Oct 23,  · The pH at absorption site• Drug pKa & GI pH• Unionised form of drug = Function of dissociation constant of the drug & pH of fluid at the absorption site Drug Lipophilicity Lipophilicity & Drug Absorption: Ideally a drug should have• Sufficient aqueous solubility to dissolve in the fluids at absorption site• Sufficient lipid.

This Special Issue aims to address the obstacles of intestinal drug absorption, novel strategies that are under current investigation, and the efforts that are being made to develop biorelevant methodologies to accurately predict oral drug absorption.

Gilberto Alves Dr. Ana Fortuna Guest Editors. Manuscript Submission Information. Paracellular absorption is the absorption of a molecule in between cells rather than into them. When does paracellular absorption mainly, or most frequently occur.

Paracellular absorption occurs mainly when higher calcium concentrations are present in the lumen, thus creating a concentration gradient between the lumen and the basolateral side. Drug Absorption Passive Diffusion Drug Permeability Paracellular Transport Release Dosage Form These keywords were added by machine and not by the authors.

This process is experimental and the keywords may be updated as the learning algorithm caskel.com by:. Apr 11,  · CACO-2 clone C2BBe1 MDR1-MDCK MDCK BCRP-MDCK Different cell lines are used as in vitro models for different purposes. Caco-2 cell monolayers predict not only intestinal absorption but also drug-drug interactions involving transporters.

Likewise, MDR1-MDCK cell monolayers are used to predict drug-drug interactions involving the efflux transporter P-glycoprotein as well as blood-brain.For an orally administered drug to have its desired pharmacological effect, the drug must reach the systemic circulation via absorption, through the intestinal epithelial layer [], which can occur via the paracellular or transcellular pathways [6,7].The paracellular pathway is the transport of drug molecules between epithelial cells and occurs by means of size-limited passive diffusion Cited by: 2.Kinetic modeling of these results suggested absorptive transport is predominantly paracellular, and led to the development of a novel mechanism of absorption stating that during oral absorption of metformin, transporter-mediated apical uptake and a lack of basolateral efflux leads to intestinal drug caskel.com: Chester Lee Costales.